Une nouvelle étude lie l'exposition à la nicotine aux métastases du cancer du sein


Cigarette smoking has been associated with a higher incidence of breast cancer spread, or metastasis, lowering the survival rate by 33% at diagnosis, however little is know about the role of nicotine in this. Titré, “Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung,” a study published in the January 20 online edition of Nature Communications, found that nicotine may promote the spread of breast cancer cells into the lungs.

“Our data shows that nicotine exposure creates an environment in the lungs that is ripe for metastatic growth,” said lead study author Kounosuke Watabe, Doctorat, who is a professor of cancer biology at Wake Forest School of Medicine, part of Wake Forest Baptist Health.

Un total de 1,077 breast cancer patients were included in the study, and the research team found that current smokers and former smokers had a higher incidence of lung metastasis in comparison to never smokers. Subsequently using a mouse model of breast cancer metastasis, the researchers found that persistent exposure to nicotine generates an inflammatory microenvironment in the lungs.

The researchers found that even after quitting nicotine for 30 journées, the incidence of distant metastasis was not reduced, suggesting an ongoing risk for breast cancer patients who are former smokers. “Based on these findings, breast cancer patients should opt for smoking cessation programs that do not use nicotine replacement products,” Watabe said. "En outre, our findings show that salidroside may be a promising therapeutic drug to help prevent smoking-induced breast cancer lung metastasis, although more research is needed.”

pendant ce temps, other studies have suggested that the cancer risk from vaping is significantly lower than that from smoking. A study titled, En comparant les dynamisations cancer des émissions de produits de nicotine vaporisés, y compris les e-cigarettes avec celles de la fumée de tabac, réalisée par le Dr William E Stephens de l'Université de St Andrews au Royaume-Uni, looked into the risks from inhaling vapor in comparison to those from inhaling smoke.

The cancer risk for several nicotine-containing aerosols were modelled, using published chemical analyses of vapour emissions and their correlational risks, and then compared to those of cigarette smoke.

« Les aérosols forment un spectre de cancer dynamisations couvrant cinq ordres de grandeur de l'air non contaminé à la fumée de tabac. émissions E-cigarettes couvrent la majeure partie de cette gamme avec une partie prépondérante de produits ayant des puissances<1% of tobacco smoke and falling within two orders of magnitude of a medicinal nicotine inhaler,” reported the study.

Popcorn lung claims resurface – and can vaping cause breast cancer?

La source: VapingPost