新研究将尼古丁暴露与乳腺癌转移联系起来

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吸烟与乳腺癌的高发有关, 或转移, 通过降低生存率 33% 诊断时, however little is know about the role of nicotine in this. 标题, “Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung,” a study published in the January 20 online edition of Nature Communications, found that nicotine may promote the spread of breast cancer cells into the lungs.

“Our data shows that nicotine exposure creates an environment in the lungs that is ripe for metastatic growth,” said lead study author Kounosuke Watabe, Ph.D., who is a professor of cancer biology at Wake Forest School of Medicine, part of Wake Forest Baptist Health.

总计 1,077 breast cancer patients were included in the study, and the research team found that current smokers and former smokers had a higher incidence of lung metastasis in comparison to never smokers. Subsequently using a mouse model of breast cancer metastasis, the researchers found that persistent exposure to nicotine generates an inflammatory microenvironment in the lungs.

The researchers found that even after quitting nicotine for 30 天, the incidence of distant metastasis was not reduced, suggesting an ongoing risk for breast cancer patients who are former smokers. “Based on these findings, breast cancer patients should opt for smoking cessation programs that do not use nicotine replacement products,” Watabe said. “此外, our findings show that salidroside may be a promising therapeutic drug to help prevent smoking-induced breast cancer lung metastasis, although more research is needed.”

与此同时, other studies have suggested that the cancer risk from vaping is significantly lower than that from smoking. A study titled, 排放的癌症效力从汽化尼古丁的产品包括电子香烟与烟草烟雾的比较, 威廉·ê·斯蒂芬斯博士在圣安德鲁斯的英国大学进行的, looked into the risks from inhaling vapor in comparison to those from inhaling smoke.

The cancer risk for several nicotine-containing aerosols were modelled, using published chemical analyses of vapour emissions and their correlational risks, and then compared to those of cigarette smoke.

“气溶胶形成癌症的效力的跨越五个数量级从洁净空气烟草烟雾的频谱. 电子烟的排放跨越极本范围内具有效力的产品优势<1% of tobacco smoke and falling within two orders of magnitude of a medicinal nicotine inhaler,” reported the study.

Popcorn lung claims resurface – and can vaping cause breast cancer?

资源: VapingPost